Aging of neurons

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  1. Cellular
    1. reduction in DNA, RNA, cerebrosides, and other components of myelin; reduction in concentration of GABA, Ach, NE, and DA
    2. accumulation of lipofuscin (oxidized lipids) in cytoplasm, reduction in volume of Nissl bodies (the main cytoplasmic RNA of neurons) and mitochondria
    3. nucleus become smaller (a.k.a. apoptosis or “dropping off”)
    4. DNA of older individuals has more numerous strand breaks, is less efficiently repaired, is more susceptible to damage by free radicals, and is fundamentally more unstable than the DNA of younger persons
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