Antibiotic induced side effects and blood dyscrasias

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  1. Beta-lactams – occasionally causes seizures, nephrotoxicity, allergic reactions
  2. Vancomycin – red man syndrome with pruritus, flushing, and erythma of the head and upper torso; treatment – benadryl; nephrotoxicity and ototoxicity are mild
  3. Aminoglycosides – nephro and ototoxicity, neuromuscular blockade
  4. Sulfonamides and trimethoprim – hematologic complications common and include agranulocytosis, hemolytic and megaloblastic anemia and thrombocytopenia (associated with glucose-6-phosphate dehydrogenase deficiency)
  5. Isoniazid, ethambutol, ethionamide, nitrofurantoin, and metronidazole, linezolid- peripheral neuropathy
  6. Rifampin – hemolytic anemia, thrombocytopenia, shock, nephrotoxicity
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