Banked blood components
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Whole blood is rarely used (even for blood loss; usually separte components are transfused: red blood cells, platelets, coagulation factors, albumin, leukocyte depleetd cellular componenets. One unit of whole blood - 450 ml blood and 63 ml preservative- with a hematocrit ranging from 36-40%. Packed red cells – 200 mL of cells after removing 200-250 ml plasma- with a hematocrit of 70-80% and stored with citrate-phosphate- dextrose- adenine(CPD- A)
- citrate binds ionized Ca and acts as an anticoagulant
- phosphate retards breakdown of 2,3 DPG
- dextrose is fuel source for red cells
- Risk of transfusion with banked blood products consist of viral infection, immunization, and effects of the substances used for preparation and storage; the autologous transfusions are associated only with the risk related to preparation and storage. Banked blood products have decreased levels of nitric oxid, resulting in post-transfusion increased frequency of myocardial infarction, heart failure, stroke, and death.