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Cerebellar liponeurocytoma is a rare tumor of adulthood characterized by advanced neuronal/neurocytic and focal lipomatous differentiation. Cerebellar liponeurocytoma corresponds to WHO Grade I or II.
Cerebellar liponeurocytoma occurs in adults during their fifth or sixth decades of life. Both sexes are affected equally.
Cerebellar liponeurocytoma may present as a cerebellar hemispheric or vermian lesion. Two cases of exophytic lesions within the CPA have been reported.
Patients present with symptoms typical for a posterior fossa lesion.
MRI shows a cystic lesion with an enhancing mural component. The lipomatous component may be hyperintense on T1-weighted imaging.
Cerebellar liponeurocytomas are cystic, soft tumors that are easily delineated from the surrounding normal cerebellum.
Cerebellar liponeurocytomas are composed of isomorphic neoplastic round cells with consistent neuronal and lipomatous differentiation. The proliferation rate is low, and mitotic figures are few.
The molecular genetics of cerebellar liponeurocytoma have not been elucidated.
Surgical resection appears to be sufficient for achieving tumor control.