CEREBELLAR LIPONEUROCYTOMA

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Contents

Definition

Cerebellar liponeurocytoma is a rare tumor of adulthood characterized by advanced neuronal/neurocytic and focal lipomatous differentiation. Cerebellar liponeurocytoma corresponds to WHO Grade I or II.

Epidemiology

Cerebellar liponeurocytoma occurs in adults during their fifth or sixth decades of life. Both sexes are affected equally.

Localization

Cerebellar liponeurocytoma may present as a cerebellar hemispheric or vermian lesion. Two cases of exophytic lesions within the CPA have been reported.

Clinical presentation

Patients present with symptoms typical for a posterior fossa lesion.

Imaging

MRI shows a cystic lesion with an enhancing mural component. The lipomatous component may be hyperintense on T1-weighted imaging.

Pathology

Macroscopy

Cerebellar liponeurocytomas are cystic, soft tumors that are easily delineated from the surrounding normal cerebellum.

Histopathology

Cerebellar liponeurocytomas are composed of isomorphic neoplastic round cells with consistent neuronal and lipomatous differentiation. The proliferation rate is low, and mitotic figures are few.

Molecular genetics

The molecular genetics of cerebellar liponeurocytoma have not been elucidated.

Prognosis

Surgical resection appears to be sufficient for achieving tumor control.

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