GABAC receptor

From WikiCNS
Jump to: navigation, search

γ(gamma)-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the brain and spinal cord.

Definition

The GABAC is a ligand-gated ion channel that is closely related to the GABAA receptor. Activation of the channel increases permeability to Cl- ions.

The GABAC receptor is less widely distributed than the A and B subtypes and is pharmacologically distinct: GABA is more potent by an order of magnitude at GABAC than at GABAA receptors, and a number of GABAA agonists (e.g., baclofen) and modulators (e.g., benzodiazepines and barbiturates) seem not to interact with GABAC receptors. GABAC receptors are found in the retina, spinal cord, superior colliculus, and pituitary

Structure

Three known subunits that assemble in pentamers.

References

1. Goodman LS, Gilman A, Brunton LL, Lazo JS, Parker KL. Goodman & Gilman's the pharmacological basis of therapeutics. 11th / ed. New York: McGraw-Hill; 2006.

Personal tools