GABA B receptor

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γ(gamma)-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the brain and spinal cord.

Definition

A metabotropic GABA receptor; interacts with Gi to inhibit adenylyl cyclase, activate K+ channels, and reduce Ca2+ conductance. Presynaptic GABAB receptors function as autoreceptors, inhibiting GABA release, and may play the same role on neurons releasing other transmitters. There are two subtypes of GABAB receptors, 1a and 1b.

Structure

Heterodimers, similar in structure to glutamate metabotropic receptors.

References

1. Goodman LS, Gilman A, Brunton LL, Lazo JS, Parker KL. Goodman & Gilman's the pharmacological basis of therapeutics. 11th / ed. New York: McGraw-Hill; 2006.

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