Imipramine

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(Tofranil)

  • One of the tricyclic antidepressants that interferes with norepinpherine and serotonin reuptake; weakly acidic
  • Used for depression and chronic pain; also effective for enuresis (especially in MS patients)
  • Eliminated by liver
  • Should not be given in conjunction with a MAO; serious interactions incude: hypertensive crises, hyperactivity, hyperpyrexia, spasticity, convulsions, coma, and death.
  • Contraindications: severe renal/liver damage, blood dyscrasia, recovering phase of MI, seizure disorder, glaucoma.
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