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  1. One of the non-subtype selective beta adrenergic antagonists
  2. Competitive antagonists of both alpha and beta adrenergic receptors; potency of the beta adrenergic blockade is fivefold to tenfold that of the alpha adrenergic blockade
  3. Blockade of alpha and beta adrenergic receptors contributes to the fall in blood pressure; alpha blockade leads to relaxation of arterial smooth muscle and vasodilation; beta blockade also contributes to fall in blood pressure in part by blocking reflex sympathetic stimulation of the heart
  4. Metabolized in the liver; ½ life is around 8 hours
  5. Administration: 20=80 mg IV pushes to a maximum of 300 mg/day, IV drip 0.5-2 mg/min, or tablets- strat 100 mg po twice daily, increase by 100 mg twice daily every 2-3 days to a maximum of 1.2 to 2.4 g/day.
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