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- O6-methylguanine-DNA methyltransferase is a DNA repair enzyme repairs the O6-methylguanine DNA adducts induced by alkylating agents used to treat GBM.
- The promoter of the MGMT gene is methylated (silenced) in up to 45% of cases, rendering it ineffective.
- This is a favorable prognostic factor in patients with GBM.
- Patients with GBM and a methylated MGMT promoter have a survival advantage when treated with concurrent temozolomide and radiation compared to those without a methylated MGMT promoter.
- MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 2005 Mar 10;352(10):997-1003.