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Protoplasmic astrocytoma is a rare variant of LGG composed of neoplastic astrocytes characterized by small cell bodies with few, flaccid processes, and containing a low content glial filaments.
These lesions are frequently associated with a long history of seizure, and are most commonly found in the fronto-temporal region of children.
Cellularity is low and mitotic activity is absent. Nuclei are uniformly round to oval. GFAP staining is variable. Mucoid degeneration and microcyst formation are characteristic. These lesions may be difficult to distinguish pathologically from pilocytic astrocytoma.