One of the primary CNS germ cell neoplasms and most commonly seen in the gonads, diencephalon (pineal and suprasellar regions), and mediastinum
- Germ cell neoplasms are divided into germinoma and nongerminomatous becaue germinomas are particularly sensitive to radiotherapy.
- Germ cell neoplasms present almost exclusively in children and young adults (choriocarcinomas and teratomas tend to present at a younger age); affects mostly males (2:1 male to female).
Treatment of germ cell tumors can be without biopsy if serum markers are definitive. Differentiated teratomas are well circumscribed and usually have a lobulated or partly cystic appearance with a mixture of ectoderm, endoderm, and mesoderm.