Uncinate seizure, olfactory aura

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Olfactory hallucination are caused by temporal seizures (uncinate fits) but may also be caused by schizophrenia or depression

  • can be caused by temporal lobe hamartoma, mesial temporal sclerosis or a glioma
    • mesial temporal sclerosis is associated with severe hippocampal neuron loss with greatest damage in Somner’s sector (CA1) and CA4 and the least damage in CA2
    • temporal lobectomy usually improves symptoms
    • mossy fiber sprouting is a pathologic feature of mesial temporal sclerosis
  • pathway may be from the amygdala which receives input from the olfactory tract to the corticomedial nucleus under the pyriform cortex
    • pyriform cortex is the primary olfactory cortex
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