Zollinger-Ellison syndrome

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  • Gastrin producing tumor; most gastrinomas arise in the pancreas and duodenum
  • 25% of gastrinomas are associated with MEN-I
  • results in multiple ulgcers with unsual gastric and intestinal location
  • symptoms

Burning, aching, gnawing or discomfort in your upper abdomen Diarrhea Nausea and vomiting Bleeding in the digestive tract Weight loss

  • treatment: resistant to medical treatment ( H2 blockers, proton pump inhibitors) and associates a high rate of recurrence; most require exploratory surgery
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